PLGA™

Sustained release pharmaceutical base material

Usage detail

Controlled-release pharmaceuticals

Usage
  • Overview
  • Properties

Overview

Mitsui PLGA is a high quality excipient for controlled-extended release of drugs, for industrial usage.

Advantages of Mitsui PLGA

PLGA
  • Least Residual Solvent
  • Well-Controlled Molecular Weight
  • Drug Master File Registered with
    - FDA(USA)
    - Health Canada(Canada)
  • cManufactured under cGMP

Properties

Properties
  • Degraded into glycolic acid and lactic acid by hydrolysis
  • Specific rate of degradation depending on its copolymer ratio and molecular weight
Physical Properties
CAS No. 26780-50-7
Chemical Formula ( C4H4O4 )x ( C6H8O4 )y
Color white to light tan
Odor odorless
Tm (Melting Point) / ℃
Tg (Glass Transition) / ℃ 45-55
Solvent CH2Cl2
CHCl3
DMF
DMSO
THF
Properties of the Standard Grade
Polymer Co-polymer Ratio *Inherent Viscosity **Molecular Weight Residual Monomer Sn Content Heavy Metals Sulphated Ash
(mol%) (dL/g) (kDa) (%) (ppm) (ppm) (%)
GLD LTD     GLD LTD      
PLGA
5-50
45-55 45-55 0.45-0.60 (50-55) < 2.0 < 2.0 < 50 < 10 < 0.1
PLGA
75-75
20-30 70-80 0.72 – 0.80 (78 – 85) < 2.0 < 2.0 < 50 < 10 < 0.1
PLGA
75-65
0.60-0.70 (62-76)
PLGA
75-50
0.45-0.55 (50-60)
  • Mitsui PLGA GRADE NAMING/li>
  • PLGA Lactide-Viscosity
  • EX : PLGA 5-50
  • Lactide 50 : 50, Viscosity 0.50 dL/g

*Inherent Viscosity : 0.5 g/dl (Chloroform), @25 C
**Molecular Weight (by GPC) : (Standard polymer-Solvent) PMMA-HFIP for PGA, PS-THF for PLGA

We also welcome your requests on customize products, for more than a demand of 5kg/year.

Contact Us

Personal Care Materials Division
TEL81-3-6253-3815
FAX81-3-6253-4236